pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization

Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H O homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, w...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-04, Vol.11 (15), p.3397-3405
Main Authors: Zuo, Jingjie, Hao, Siyuan, Li, Wenqiu, Huang, Haowu, Liu, Mingxing, Guo, Huiling
Format: Article
Language:English
Subjects:
Disulfiram
Engineering
Glutathione
Homeostasis
Hydrogen Peroxide
Hydrogen-Ion Concentration
Neoplasms
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Summary:Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H O homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, we engineer a novel pH-responsive nanocatalyst to disrupt intracellular H O homeostasis through consuming glutathione (GSH), elevating H O and restraining H O elimination, as well as achieving a combination of CDT and chemotherapy (CT) through sensitized DSF. In the formulation, amplified CDT synergized enhanced CT significantly, strengthening the tumor therapeutic efficacy and . This work not only solves intracellular redox homeostasis disruption, but also realizes the re-use of old drugs, providing new insights for CDT-based multimodal cancer therapy.
ISSN:2050-750X
2050-7518
DOI:10.1039/D3TB00033H