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pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization
Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H O homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, w...
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| Published in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-04, Vol.11 (15), p.3397-3405 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c996-c7a53d68e9e5e10f2f12d4cd7e1325a181c9826c6b4bb7f9fe56e979d31c80a3 |
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| cites | cdi_FETCH-LOGICAL-c996-c7a53d68e9e5e10f2f12d4cd7e1325a181c9826c6b4bb7f9fe56e979d31c80a3 |
| container_end_page | 3405 |
| container_issue | 15 |
| container_start_page | 3397 |
| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
| container_volume | 11 |
| creator | Zuo, Jingjie Hao, Siyuan Li, Wenqiu Huang, Haowu Liu, Mingxing Guo, Huiling |
| description | Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H
O
homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, we engineer a novel pH-responsive nanocatalyst to disrupt intracellular H
O
homeostasis through consuming glutathione (GSH), elevating H
O
and restraining H
O
elimination, as well as achieving a combination of CDT and chemotherapy (CT) through sensitized DSF. In the formulation, amplified CDT synergized enhanced CT significantly, strengthening the tumor therapeutic efficacy
and
. This work not only solves intracellular redox homeostasis disruption, but also realizes the re-use of old drugs, providing new insights for CDT-based multimodal cancer therapy. |
| doi_str_mv | 10.1039/D3TB00033H |
| format | article |
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O
homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, we engineer a novel pH-responsive nanocatalyst to disrupt intracellular H
O
homeostasis through consuming glutathione (GSH), elevating H
O
and restraining H
O
elimination, as well as achieving a combination of CDT and chemotherapy (CT) through sensitized DSF. In the formulation, amplified CDT synergized enhanced CT significantly, strengthening the tumor therapeutic efficacy
and
. This work not only solves intracellular redox homeostasis disruption, but also realizes the re-use of old drugs, providing new insights for CDT-based multimodal cancer therapy.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/D3TB00033H</identifier><identifier>PMID: 36974586</identifier><language>eng</language><publisher>England</publisher><subject>Disulfiram ; Engineering ; Glutathione ; Homeostasis ; Hydrogen Peroxide ; Hydrogen-Ion Concentration ; Neoplasms</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2023-04, Vol.11 (15), p.3397-3405</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c996-c7a53d68e9e5e10f2f12d4cd7e1325a181c9826c6b4bb7f9fe56e979d31c80a3</citedby><cites>FETCH-LOGICAL-c996-c7a53d68e9e5e10f2f12d4cd7e1325a181c9826c6b4bb7f9fe56e979d31c80a3</cites><orcidid>0000-0003-4917-5947 ; 0000-0001-9732-747X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36974586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuo, Jingjie</creatorcontrib><creatorcontrib>Hao, Siyuan</creatorcontrib><creatorcontrib>Li, Wenqiu</creatorcontrib><creatorcontrib>Huang, Haowu</creatorcontrib><creatorcontrib>Liu, Mingxing</creatorcontrib><creatorcontrib>Guo, Huiling</creatorcontrib><title>pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H
O
homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, we engineer a novel pH-responsive nanocatalyst to disrupt intracellular H
O
homeostasis through consuming glutathione (GSH), elevating H
O
and restraining H
O
elimination, as well as achieving a combination of CDT and chemotherapy (CT) through sensitized DSF. In the formulation, amplified CDT synergized enhanced CT significantly, strengthening the tumor therapeutic efficacy
and
. This work not only solves intracellular redox homeostasis disruption, but also realizes the re-use of old drugs, providing new insights for CDT-based multimodal cancer therapy.</description><subject>Disulfiram</subject><subject>Engineering</subject><subject>Glutathione</subject><subject>Homeostasis</subject><subject>Hydrogen Peroxide</subject><subject>Hydrogen-Ion Concentration</subject><subject>Neoplasms</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpFkE1PwzAMhiMEYmjswg9AOSMVkqZNkyOMjyJN2oEduFVu6rCgLa2Sbmj8ejoNxsF6bfmRLT2EXHF2y5nQd49i8cAYE6I8IRcpy1lS5FydHnv2PiKTGD8HhikulcjOyUhIXWS5khfkqyuTgLFrfXRbpB58a6CH1S721LaBol-CN85_UDMkBtovMUC3o1sHtKQpnQ-1bNfYxh6ii7RxMWy63rWegm_242ZlXYA1jTj86N037JeX5MzCKuLkN8fk7flpMS2T2fzldXo_S4zWMjEF5KKRCjXmyJlNLU-bzDQFcpHmwBU3WqXSyDqr68Jqi7lEXehGcKMYiDG5OVw1oY0xoK264NYQdhVn1V5f9a9vgK8PcLep19gc0T9Z4gefvmyZ</recordid><startdate>20230412</startdate><enddate>20230412</enddate><creator>Zuo, Jingjie</creator><creator>Hao, Siyuan</creator><creator>Li, Wenqiu</creator><creator>Huang, Haowu</creator><creator>Liu, Mingxing</creator><creator>Guo, Huiling</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4917-5947</orcidid><orcidid>https://orcid.org/0000-0001-9732-747X</orcidid></search><sort><creationdate>20230412</creationdate><title>pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization</title><author>Zuo, Jingjie ; Hao, Siyuan ; Li, Wenqiu ; Huang, Haowu ; Liu, Mingxing ; Guo, Huiling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c996-c7a53d68e9e5e10f2f12d4cd7e1325a181c9826c6b4bb7f9fe56e979d31c80a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Disulfiram</topic><topic>Engineering</topic><topic>Glutathione</topic><topic>Homeostasis</topic><topic>Hydrogen Peroxide</topic><topic>Hydrogen-Ion Concentration</topic><topic>Neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuo, Jingjie</creatorcontrib><creatorcontrib>Hao, Siyuan</creatorcontrib><creatorcontrib>Li, Wenqiu</creatorcontrib><creatorcontrib>Huang, Haowu</creatorcontrib><creatorcontrib>Liu, Mingxing</creatorcontrib><creatorcontrib>Guo, Huiling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuo, Jingjie</au><au>Hao, Siyuan</au><au>Li, Wenqiu</au><au>Huang, Haowu</au><au>Liu, Mingxing</au><au>Guo, Huiling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2023-04-12</date><risdate>2023</risdate><volume>11</volume><issue>15</issue><spage>3397</spage><epage>3405</epage><pages>3397-3405</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Due to the powerful redox homeostasis and inefficiency of monotherapy, chemodynamic therapy (CDT) is clinically limited. Despite great efforts, the design of CDT nanosystems with specific H
O
homeostasis and effective integration of multiple treatments remains a great challenge. Therefore, herein, we engineer a novel pH-responsive nanocatalyst to disrupt intracellular H
O
homeostasis through consuming glutathione (GSH), elevating H
O
and restraining H
O
elimination, as well as achieving a combination of CDT and chemotherapy (CT) through sensitized DSF. In the formulation, amplified CDT synergized enhanced CT significantly, strengthening the tumor therapeutic efficacy
and
. This work not only solves intracellular redox homeostasis disruption, but also realizes the re-use of old drugs, providing new insights for CDT-based multimodal cancer therapy.</abstract><cop>England</cop><pmid>36974586</pmid><doi>10.1039/D3TB00033H</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4917-5947</orcidid><orcidid>https://orcid.org/0000-0001-9732-747X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2023-04, Vol.11 (15), p.3397-3405 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D3TB00033H |
| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Disulfiram Engineering Glutathione Homeostasis Hydrogen Peroxide Hydrogen-Ion Concentration Neoplasms |
| title | pH-responsive nanocatalyst for enhancing cancer therapy via H 2 O 2 homeostasis disruption and disulfiram sensitization |
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