Choline phosphate lipid-hitchhiked near-infrared BODIPY nanoparticles for enhanced phototheranostics

Phototheranostics integrating optical imaging and phototherapy has attracted extensive attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. Herein, we develop a multifunctional ther...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-06, Vol.11 (24), p.5586-5593
Main Authors: Geng, Huafeng, Lin, Wenhai, Liu, Junbao, Pei, Qing, Xie, Zhigang
Format: Article
Language:English
Subjects:
Anticancer properties
Assembly
Benzene
Boron
Choline
Fluorescence
Hydrophobicity
Imaging
Irradiation
Light therapy
Lipids
Nanoparticles
Near infrared radiation
Phospholipids
Photodynamic therapy
Phototherapy
Photothermal conversion
Singlet oxygen
Tumors
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Summary:Phototheranostics integrating optical imaging and phototherapy has attracted extensive attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. Herein, we develop a multifunctional theranostic nanoplatform prepared from the co-assembly of NIR boron dipyrromethene (BODIPY) with a cooperative D-π-A structure of a thiophene-BODIPY core and benzene-diethylamino, and a choline phosphate lipid. The as-fabricated nanoparticles (DBNPs) exhibited desirable NIR absorption, uniform spherical morphology and good colloidal stability. The elaborate molecular design and supramolecular assembly endowed DBNPs with desirable PDT and PTT activities. Upon 808 nm laser irradiation, the DBNPs efficiently generated active singlet oxygen and regional hyperpyrexia, with a photothermal conversion efficiency of 37.6%. The excellent PDT and PTT performance of DBNPs boosted the potent in vitro and in vivo anti-tumor effects. In addition, these nanoparticles manifested their good capability of NIR fluorescence imaging of tumors. Overall, the DBNPs provide a paradigm for delivering hydrophobic phototherapy molecules with phospholipids for enhanced tumor treatment and imaging. A theranostic nanoplatform (DBNPs) was developed via co-assembly of near infrared boron dipyrromethene and choline phosphate lipid. The elaborate molecular design and supramolecular assembly endowed DBNPs with desirable phototherapeutic effect.
ISSN:2050-750X
2050-7518
DOI:10.1039/d3tb00175j