A light-sensitive protein-based wearable pH biometer

Bacteriorhodopsin is a biological material with excellent photosensitivity properties. It can directly convert optical signals into electrical signals and is widely used in various biosensors. Here, we present a bR-based wearable pH biometer that can be used to monitor wound infection. The mechanism...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-01, Vol.12 (5), p.128-1216
Main Authors: Li, Wenxue, Chen, Siyuan, Xie, Shiwang, Lu, Xianmao, Li, Zhou, Lv, Yujia, Luo, Dan
Format: Article
Language:English
Subjects:
Bacteriorhodopsin
Biological materials
Biosensors
Irradiation
Light irradiation
Optical communication
Optical properties
pH effects
Photoelectricity
Photosensitivity
Transient photovoltage
Wearable technology
Wound infection
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Summary:Bacteriorhodopsin is a biological material with excellent photosensitivity properties. It can directly convert optical signals into electrical signals and is widely used in various biosensors. Here, we present a bR-based wearable pH biometer that can be used to monitor wound infection. The mechanism of the pH-sensitive effect of the bR electrode is explained, which generates a transient photovoltage under light irradiation and a negative photovoltage when the lamp is turned off. Since the photoelectric signal of bR is affected by different pH values, the photovoltage is changed by adjusting the pH value. The ratio ( V n / V p ) of negative photovoltage ( V n ) to positive photovoltage ( V p ) has a good linear relationship ( R 2 = 0.9911) in the pH range of 4.0-10.0. In vitro experiments using rats as a model confirmed that this wearable pH biometer can monitor pH changes that occur in wound infection. A bR-based wearable pH biometer is fabricated to monitor infected wound. Under illumination, bR generate a positive photovoltage ( V p ) and negative photovoltage ( V n ), and the ratio ( V n / V p ) present a linear relationship in the pH range of 4.0-10.0.
ISSN:2050-750X
2050-7518
DOI:10.1039/d3tb02466k