A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis

A small-molecule Fenton reagent, integrating ferrocene with a carbonic anhydrase inhibitor, was designed to intelligently regulate intracellular acidosis for self-augmented chemodynamic therapy. Acidosis coupled with up-regulated ROS levels demonstrated potent cytotoxicity and effective tumor suppre...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-04, Vol.6 (36), p.4773-4776
Main Authors: Wang, Kaiye, Liu, Xiaohan, Jia, Yuting, Pan, Limeng, Shi, Mingwan, Pan, Wei, Li, Na, Tang, Bo
Format: Article
Language:English
Subjects:
Acidosis
Carbonic anhydrase
Reagents
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Summary:A small-molecule Fenton reagent, integrating ferrocene with a carbonic anhydrase inhibitor, was designed to intelligently regulate intracellular acidosis for self-augmented chemodynamic therapy. Acidosis coupled with up-regulated ROS levels demonstrated potent cytotoxicity and effective tumor suppression. A small-molecule Fenton reagent was developed to self-augment chemodynamic therapy by intelligently regulating intracellular acidosis.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc00760c