Palladium/norbornene-catalyzed C-H/N-H cycloaddition of carbazoles with 2-halobenzoic acid derivatives

An example of palladium/norbornene-catalyzed C-H/N-H cycloaddition of carbazoles with 2-bromobenzoic acids is presented, in which a collection of important carbazoles is expeditiously obtained. Derivatives, including acyl halides, α-oxocarboxylic acids, anhydrides, and even amides, are all allowed....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-10, Vol.6 (82), p.11746-11749
Main Authors: Liu, Shilei, Nan, Jiang, An, Nan, Cao, Rui, Zhu, Lanxin, Yan, Qiang, Zhang, Hanqing, Liang, Chengyuan
Format: Article
Language:English
Subjects:
Amides
Carbazoles
Cycloaddition
Halides
Palladium
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Summary:An example of palladium/norbornene-catalyzed C-H/N-H cycloaddition of carbazoles with 2-bromobenzoic acids is presented, in which a collection of important carbazoles is expeditiously obtained. Derivatives, including acyl halides, α-oxocarboxylic acids, anhydrides, and even amides, are all allowed. Preliminary mechanistic studies reveal that a rare six-membered spiropalladacycle is involved. An example of palladium/norbornene-catalyzed C-H/N-H cycloaddition of carbazoles with 2-bromobenzoic acids is presented, in which a collection of important carbazoles is expeditiously obtained.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc03720k