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Plant-based diet index and all-cause and cause‑specific mortality: a prospective study
Background: A plant-based dietary pattern has been recently suggested to have health benefits. However, its relation to mortality is not completely consistent in prior studies. We aimed to investigate whether plant-based diet was associated with lower death risk in Prostate, Lung, Colorectal and Ova...
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creator | Xu, Xin Yan, Minqing Huo, Sijun Meng, Shuai yuan, changzheng Wang, Ping |
description | Background: A plant-based dietary pattern has been recently suggested to have health benefits. However, its relation to mortality is not completely consistent in prior studies. We aimed to investigate whether plant-based diet was associated with lower death risk in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening study. Methods: We included 91,414 participants from the PLCO study. Dietary data were collected by a diet history questionnaire (DHQ). We used three plant-based diet indices including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression model. Results: During a median of 17.1 years of follow-up, we documented 19,456 deaths, including 5,489 deaths from cardiovascular disease (CVD) and 6,172 deaths from cancer. Comparing the highest versus lowest quintiles of PDI, the multivariable-adjusted HR of all-cause mortality was 0.83 (95% CI 0.79-0.87, P for trend < 0.001). Those in the highest quintile of PDI also had lower risks of CVD mortality (HR 0.87, 95% CI 0.79-0.94, P for trend < 0.001) and cancer mortality (HR 0.89, 95% CI 0.82-0.96, P for trend < 0.001) compared to those in the lowest quintile. Participants in the highest quintile of hPDI had a decreased risk of all-cause and cause-specific mortality, whereas participants with the highest uPDI scores had an increased death risk. Conclusion: greater adherence to a plant-based dietary pattern was significantly associated with lower all-cause and cause-specific mortality. |
doi_str_mv | 10.1039/D4FO04242E |
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However, its relation to mortality is not completely consistent in prior studies. We aimed to investigate whether plant-based diet was associated with lower death risk in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening study. Methods: We included 91,414 participants from the PLCO study. Dietary data were collected by a diet history questionnaire (DHQ). We used three plant-based diet indices including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression model. Results: During a median of 17.1 years of follow-up, we documented 19,456 deaths, including 5,489 deaths from cardiovascular disease (CVD) and 6,172 deaths from cancer. Comparing the highest versus lowest quintiles of PDI, the multivariable-adjusted HR of all-cause mortality was 0.83 (95% CI 0.79-0.87, P for trend < 0.001). Those in the highest quintile of PDI also had lower risks of CVD mortality (HR 0.87, 95% CI 0.79-0.94, P for trend < 0.001) and cancer mortality (HR 0.89, 95% CI 0.82-0.96, P for trend < 0.001) compared to those in the lowest quintile. Participants in the highest quintile of hPDI had a decreased risk of all-cause and cause-specific mortality, whereas participants with the highest uPDI scores had an increased death risk. Conclusion: greater adherence to a plant-based dietary pattern was significantly associated with lower all-cause and cause-specific mortality.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/D4FO04242E</identifier><language>eng</language><ispartof>Food & function, 2025</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids></links><search><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Yan, Minqing</creatorcontrib><creatorcontrib>Huo, Sijun</creatorcontrib><creatorcontrib>Meng, Shuai</creatorcontrib><creatorcontrib>yuan, changzheng</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><title>Plant-based diet index and all-cause and cause‑specific mortality: a prospective study</title><title>Food & function</title><description>Background: A plant-based dietary pattern has been recently suggested to have health benefits. However, its relation to mortality is not completely consistent in prior studies. We aimed to investigate whether plant-based diet was associated with lower death risk in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening study. Methods: We included 91,414 participants from the PLCO study. Dietary data were collected by a diet history questionnaire (DHQ). We used three plant-based diet indices including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression model. Results: During a median of 17.1 years of follow-up, we documented 19,456 deaths, including 5,489 deaths from cardiovascular disease (CVD) and 6,172 deaths from cancer. Comparing the highest versus lowest quintiles of PDI, the multivariable-adjusted HR of all-cause mortality was 0.83 (95% CI 0.79-0.87, P for trend < 0.001). Those in the highest quintile of PDI also had lower risks of CVD mortality (HR 0.87, 95% CI 0.79-0.94, P for trend < 0.001) and cancer mortality (HR 0.89, 95% CI 0.82-0.96, P for trend < 0.001) compared to those in the lowest quintile. Participants in the highest quintile of hPDI had a decreased risk of all-cause and cause-specific mortality, whereas participants with the highest uPDI scores had an increased death risk. Conclusion: greater adherence to a plant-based dietary pattern was significantly associated with lower all-cause and cause-specific mortality.</description><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNqVjr0OgjAcxBujiURZfILOJmj50FBXhbjp4MBG_tKS1FQgbTGy-Qq-ok8iEI2zt9zvcjccQjOXLFzi0-UuiA8k8AIvGiDLa8lZr0gy_HJA12Nka30hrXxKQxpaKDlKKIxzBs0ZZoIbLArG7xgKhkFKJ4Na8z719Ho8dcUzkYsMX0tlQArTbDDgSpVdYcSNY21q1kzRKAepuf3xCZrH0Wm7d7J2qRXP00qJK6gmdUna3U9_9_2_xm9PIkxI</recordid><startdate>2025</startdate><enddate>2025</enddate><creator>Xu, Xin</creator><creator>Yan, Minqing</creator><creator>Huo, Sijun</creator><creator>Meng, Shuai</creator><creator>yuan, changzheng</creator><creator>Wang, Ping</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2025</creationdate><title>Plant-based diet index and all-cause and cause‑specific mortality: a prospective study</title><author>Xu, Xin ; Yan, Minqing ; Huo, Sijun ; Meng, Shuai ; yuan, changzheng ; Wang, Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_1039_D4FO04242E3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Yan, Minqing</creatorcontrib><creatorcontrib>Huo, Sijun</creatorcontrib><creatorcontrib>Meng, Shuai</creatorcontrib><creatorcontrib>yuan, changzheng</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><collection>CrossRef</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xin</au><au>Yan, Minqing</au><au>Huo, Sijun</au><au>Meng, Shuai</au><au>yuan, changzheng</au><au>Wang, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant-based diet index and all-cause and cause‑specific mortality: a prospective study</atitle><jtitle>Food & function</jtitle><date>2025</date><risdate>2025</risdate><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Background: A plant-based dietary pattern has been recently suggested to have health benefits. However, its relation to mortality is not completely consistent in prior studies. We aimed to investigate whether plant-based diet was associated with lower death risk in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening study. Methods: We included 91,414 participants from the PLCO study. Dietary data were collected by a diet history questionnaire (DHQ). We used three plant-based diet indices including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression model. Results: During a median of 17.1 years of follow-up, we documented 19,456 deaths, including 5,489 deaths from cardiovascular disease (CVD) and 6,172 deaths from cancer. Comparing the highest versus lowest quintiles of PDI, the multivariable-adjusted HR of all-cause mortality was 0.83 (95% CI 0.79-0.87, P for trend < 0.001). Those in the highest quintile of PDI also had lower risks of CVD mortality (HR 0.87, 95% CI 0.79-0.94, P for trend < 0.001) and cancer mortality (HR 0.89, 95% CI 0.82-0.96, P for trend < 0.001) compared to those in the lowest quintile. Participants in the highest quintile of hPDI had a decreased risk of all-cause and cause-specific mortality, whereas participants with the highest uPDI scores had an increased death risk. Conclusion: greater adherence to a plant-based dietary pattern was significantly associated with lower all-cause and cause-specific mortality.</abstract><doi>10.1039/D4FO04242E</doi></addata></record> |
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title | Plant-based diet index and all-cause and cause‑specific mortality: a prospective study |
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