Dual-labelled polymeric micelles for singlet oxygen reporting in biological systems

Visualizing singlet oxygen ( 1 O 2 ) in biological systems could greatly enhance our understanding of its biological roles and offer new diagnostics and therapeutics. However, 1 O 2 is unstable and highly reactive, making its detection in living systems a significant challenge. To address this, we h...

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Bibliographic Details
Published in:Molecular systems design & engineering 2025
Main Authors: Nakagawa, Yasuhiro, Mizuno, Hayato Laurence, Ushimaru, Yuta, Norimatsu, Jumpei, Igarashi, Kazunori, Masuda, Keita, Takai, Madoka, Anraku, Yasutaka, Cabral, Horacio
Format: Article
Language:English
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Summary:Visualizing singlet oxygen ( 1 O 2 ) in biological systems could greatly enhance our understanding of its biological roles and offer new diagnostics and therapeutics. However, 1 O 2 is unstable and highly reactive, making its detection in living systems a significant challenge. To address this, we have developed dually-labelled polymeric micelles designed to trace both the location and levels of 1 O 2 .
ISSN:2058-9689
2058-9689
DOI:10.1039/D4ME00105B