Palladium-catalyzed cascade cyclization of α,β-unsaturated N -tosylhydrazones with iodoarenes: access to 2 H -chromenes and 2 H -quinolines

A palladium-catalyzed cascade reaction of α,β-unsaturated -tosylhydrazones with iodoarene derivatives containing a nucleophilic group has been developed, which provides facile access to 2 -chromenes and 2 -quinolines, respectively. Additionally, the double Pd-carbene migratory insertion/nucleophilic...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-11, Vol.22 (46), p.9121-9124
Main Authors: Zheng, Yiyi, Zhu, Xi-Wei, Pan, Yi-Yun, Sun, Fei, Yao, Long, Wu, Xin-Xing
Format: Article
Language:English
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Summary:A palladium-catalyzed cascade reaction of α,β-unsaturated -tosylhydrazones with iodoarene derivatives containing a nucleophilic group has been developed, which provides facile access to 2 -chromenes and 2 -quinolines, respectively. Additionally, the double Pd-carbene migratory insertion/nucleophilic substitution processes for the synthesis of a ternary heterocyclic skeleton were possible in the developed catalytic system.
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob01300j