Tuning nanoparticles' internal structure: fluorinated single-chain nanoparticles (SCNPs) generated by chain collapse of random copolymers

The generation of nanosized compartments in single chain nanoparticles (SCNPs) is a promising approach to generate individualized confinement-zones on a small scale for drug-encapsulation or catalysis. We here report the synthesis and characterization of compartmented, fluorinated SCNPs generated by...

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Bibliographic Details
Published in:Polymer chemistry 2024-07, Vol.15 (29), p.2949-2958
Main Authors: Alqaisi, Marah, Thümmler, Justus F, Lehmann, Florian, Schmitt, Franz-Josef, Lentz, Leonie, Rieder, Fabian, Hinderberger, Dariush, Binder, Wolfgang H
Format: Article
Language:English
Subjects:
Aliphatic compounds
Alkynes
Chemical reactions
Chemical synthesis
Compartments
Continuous radiation
Copolymers
Crosslinking
Electron paramagnetic resonance
Fluorination
Hydrophobicity
Monomers
Nanoparticles
Polyethylene glycol
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Summary:The generation of nanosized compartments in single chain nanoparticles (SCNPs) is a promising approach to generate individualized confinement-zones on a small scale for drug-encapsulation or catalysis. We here report the synthesis and characterization of compartmented, fluorinated SCNPs generated by single-chain collapse of amphiphilic copolymers. Polyethylene glycol (PEG) functionalized monomers were utilized as hydrophilic moieties, while hydrophobic residues were introduced using different mole fractions of either aliphatic or fluorinated monomers. Single chain collapse and subsequently crosslinking via copper-catalyzed azide-alkyne click reactions in selective and non-selective solvents yields internally structured SCNPs with hydrodynamic radii of 2.5-5.8 nm. All of the SCNPs exhibited water solubility, but displayed different compartmentations sized
ISSN:1759-9954
1759-9962
DOI:10.1039/d4py00355a