Nanozymes: a promising solution for dental antibacterial applications

Dental diseases pose significant public health challenges globally, affecting millions with conditions exacerbated by microbial-induced inflammation. Traditional natural enzymes, despite their antibacterial and anti-inflammatory capabilities, are limited by operational stability and environmental se...

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Bibliographic Details
Published in:RSC advances 2024-11, Vol.14 (5), p.36945-36959
Main Authors: Liu, Lipeng, Zhang, Yaoyuan, Ju, Tianjuan, Chen, Xutao, Li, Xinwei, Wu, Li-an
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Chemistry
Cost effectiveness
Dental caries
Dental materials
Enzymes
Microorganisms
Nanomaterials
Public health
Stability
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Summary:Dental diseases pose significant public health challenges globally, affecting millions with conditions exacerbated by microbial-induced inflammation. Traditional natural enzymes, despite their antibacterial and anti-inflammatory capabilities, are limited by operational stability and environmental sensitivity. This review explores the revolutionary realm of nanozyme-artificial enzymes made from nanomaterials-which offer enhanced stability, cost-effectiveness, and ease of modification. We discuss the advent of nanozymes since their first recognition in 2007, emphasizing their enzyme-mimicking capabilities and applications in dental medicine, particularly for dental caries, pulpitis, periodontitis and peri-implantitis. This paper presents a comprehensive analysis of nanozymes' classification, mechanisms, and emerging applications, shedding light on their potential to revolutionize dental antibacterial treatments and addressing current challenges and future perspectives in their development. This review analyzes nanozyme classification, mechanisms, and emerging applications, shedding light on their potential to revolutionize dental antibacterial treatments and addressing current challenges and future perspectives in their development.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra07303g