Recent advances in fluorescent probes for fatty liver imaging by detecting lipid droplets

Fatty liver, a major health problem worldwide, is closely associated with aberrant accumulation and alteration of energy storage organelles, lipid droplets (LDs), in the disease process. Fluorescent probes with excellent optical performance, high sensitivity/selectivity and real-time monitoring have...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-10, Vol.12 (4), p.1149-1162
Main Authors: He, Long, Li, Hang, Tang, Yao, Ren, Tian-Bing, Yuan, Lin
Format: Article
Language:English
Subjects:
Droplets
Energy storage
Fatty liver
Fluorescent indicators
I.R. radiation
Infrared imagery
Infrared imaging
Lipids
Liver
Medical imaging
Near infrared radiation
Organelles
Probes
Real time
Wavelengths
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Summary:Fatty liver, a major health problem worldwide, is closely associated with aberrant accumulation and alteration of energy storage organelles, lipid droplets (LDs), in the disease process. Fluorescent probes with excellent optical performance, high sensitivity/selectivity and real-time monitoring have emerged as an attractive tool for the detection of LDs used in the diagnosis of fatty liver. In this review, we summarize various probes based on different response mechanisms to image LDs in the fatty liver process using different excitation imaging modes and emission wavelengths, including the visible to the near-infrared, two/three-photon, and the second near-infrared region. The perspectives and barriers associated with the reported lipid droplet (LD) probes for future development are also discussed. This review summarizes various probes for imaging LDs in the fatty liver process using different excitation imaging modes and emission wavelengths, as well as analyzing the achievements, challenges and future development trends in this field.
ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d4tb01741b