Enzyme-linked immunosorbent assay for ondansetron captured from airborne samples

A simple and relatively rapid enzyme-linked immunosorbant assay method for the anti-emetic drug ondansetron has been developed for its quantitation in solution. This has been optimised for use with samples that have been obtained following extraction of filters after the drug's capture from air...

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Bibliographic Details
Published in:Analyst (London) 1998-05, Vol.123 (5), p.1121-1126
Main Authors: HRECZUK-HIRST, D, ROWELL, F. J, REEVE, R. N, CUMMING, R. H, GUEST, I
Format: Article
Language:English
Subjects:
Air Pollutants, Occupational
Analysis
Antiemetics - analysis
Biological and medical sciences
General pharmacology
Medical sciences
Ondansetron - analysis
Pharmacology. Drug treatments
Serotonin Antagonists - analysis
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Summary:A simple and relatively rapid enzyme-linked immunosorbant assay method for the anti-emetic drug ondansetron has been developed for its quantitation in solution. This has been optimised for use with samples that have been obtained following extraction of filters after the drug's capture from air samples in the workplace. The assay has the sample throughput (40 duplicate samples in 3 h), specificity, sensitivity (LOD of 10.5 ng drug ml-1) and precision (RSD < 11%) necessary for its use in determining airborne concentrations of ondansetron in such samples as part of an occupational health and hygiene monitoring programme.
ISSN:0003-2654
1364-5528
DOI:10.1039/a708204e