Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds

Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-09 (35), p.4414
Main Authors: Yang, Zhimou, Xu, Keming, Wang, Ling, Gu, Hongwei, Wei, Heng, Zhang, Mingjie, Xu, Bing
Format: Article
Language:English
Subjects:
Animals
Circular Dichroism
Drug Design
Fluorenes
Hydrogels
Leucine - analogs & derivatives
Mice
Mice, Inbred ICR
Models, Molecular
Radiation Injuries, Experimental - drug therapy
Radiation Injuries, Experimental - mortality
Radiation Injuries, Experimental - pathology
Uranium Compounds - antagonists & inhibitors
Uranium Compounds - toxicity
Water - chemistry
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Description
Summary:Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.
ISSN:1359-7345
1364-548X
DOI:10.1039/b507314f