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Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore
A highly potent CXCR4 antagonist 2 [cyclo (-D-Tyr1-Arg2-Arg3-Nal4-Gly5-)] has previously been identified by screening cyclic pentapeptide libraries that were designed based on pharmacophore residues of a 14-residue peptidic CXCR4 antagonist 1. In the present study, D-Tyr and Arg in peptide 2 were re...
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| Published in: | Organic & biomolecular chemistry 2008-01, Vol.6 (23), p.4374 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c391t-de271e4aa9474d7293f9cd554a32c80eaf1e51e8a29702e1f3170fc87d0ff0cc3 |
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| cites | cdi_FETCH-LOGICAL-c391t-de271e4aa9474d7293f9cd554a32c80eaf1e51e8a29702e1f3170fc87d0ff0cc3 |
| container_end_page | |
| container_issue | 23 |
| container_start_page | 4374 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 6 |
| creator | Tanaka, Tomohiro Tsutsumi, Hiroshi Nomura, Wataru Tanabe, Yasuaki Ohashi, Nami Esaka, Ai Ochiai, Chihiro Sato, Jun Itotani, Kyoko Murakami, Tsutomu Ohba, Kenji Yamamoto, Naoki Fujii, Nobutaka Tamamura, Hirokazu |
| description | A highly potent CXCR4 antagonist 2 [cyclo (-D-Tyr1-Arg2-Arg3-Nal4-Gly5-)] has previously been identified by screening cyclic pentapeptide libraries that were designed based on pharmacophore residues of a 14-residue peptidic CXCR4 antagonist 1. In the present study, D-Tyr and Arg in peptide 2 were replaced by a bicyclic aromatic amino acid and a cationic amino acid, respectively, and their binding activity for CXCR4 was evaluated for identification of the novel pharmacophore. |
| doi_str_mv | 10.1039/b812029c |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2008-01, Vol.6 (23), p.4374 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_b812029c |
| source | Royal Society of Chemistry Journals |
| subjects | Animals Cattle Cell Line Drug Discovery HIV-1 - drug effects Humans Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Oligopeptides - toxicity Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Peptides, Cyclic - toxicity Receptors, CXCR4 - antagonists & inhibitors Structure-Activity Relationship Tyrosine - chemistry |
| title | Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore |
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