Facile one-pot preparation of calcite mesoporous carrier for sustained and targeted drug release for cancer cells

Herein, mesoporous calcite/chondroitin sulfate hybrid microrods are prepared through a one-pot method. Biological assays indicate that the microrods might be used as good active targeted drug delivery carriers to treat tumor tissues with high specificity and low toxic side effects.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-11, Vol.48 (86), p.10636
Main Authors: Guo, Yuming, Zhang, Jie, Jiang, Lili, Shi, Xiaoman, Yang, Lin, Fang, Qilong, Fang, Hui, Wang, Kui, Jiang, Kai
Format: Article
Language:English
Subjects:
Calcium Carbonate - chemistry
Cell Survival - drug effects
Chondroitin Sulfates - chemistry
Doxorubicin - toxicity
Drug Carriers - chemistry
HeLa Cells
Humans
Hydrogen-Ion Concentration
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Porosity
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Summary:Herein, mesoporous calcite/chondroitin sulfate hybrid microrods are prepared through a one-pot method. Biological assays indicate that the microrods might be used as good active targeted drug delivery carriers to treat tumor tissues with high specificity and low toxic side effects.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc35103j