Molecular iodine catalyzed one-pot multicomponent reactions for the synthesis of dihydrochromeno[4,3-]pyrazolo[4,3-]pyridin-6(7)-ones

A simple and concise method catalyzed by molecular iodine has been reported for the synthesis of a series of dihydrochromeno[4,3- b ]pyrazolo[4,3- e ]pyridin-6(7 H )-ones ( 1 ) using a multicomponent domino reaction of aromatic aldehydes, 4-hydroxycoumarin derivatives and 3-aminopyrazoles. The same...

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Bibliographic Details
Published in:RSC advances 2013-01, Vol.3 (36), p.1575-15711
Main Authors: Pal, Suman, Khan, Md. Nasim, Karamthulla, Shaik, Choudhury, Lokman H
Format: Article
Language:English
Subjects:
Aldehydes
Catalysts
Column chromatography
Derivatives
Hydrates
Hydrazines
Iodine
Synthesis
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Summary:A simple and concise method catalyzed by molecular iodine has been reported for the synthesis of a series of dihydrochromeno[4,3- b ]pyrazolo[4,3- e ]pyridin-6(7 H )-ones ( 1 ) using a multicomponent domino reaction of aromatic aldehydes, 4-hydroxycoumarin derivatives and 3-aminopyrazoles. The same catalyst was also found useful for the four component reaction of aromatic aldehydes, 4-hydroxycoumarin, benzoylacetonitrile and hydrazine hydrate. The notable advantages of this method are: good yields, no column chromatography, environmentally friendly catalyst and applicability for diversity oriented synthesis of substituted dihydrochromeno pyrazolo pyridin-6(7 H )-one scaffolds using both three and four component reactions. A facile method has been reported for the synthesis of a series of dihydrochromeno[4,3- b ]pyrazolo[4,3- e ]pyridin-6(7 H )-ones using molecular iodine catalyzed multi-component reactions.
ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra41569d