REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine

In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life‐ and material‐science communities. Recent advances in tissue engineering, gene therapy, gene‐function analysis, animal‐free drug testing, drug discovery, biopharmaceutica...

Full description

Saved in:
Bibliographic Details
Published in:Biotechnology and applied biochemistry 2004-02, Vol.39 (1), p.3-16
Main Authors: Kelm, Jens M., Kramer, Beat P., Gonzalez-Nicolini, Valeria, Ley, Bettina, Fussenegger, Martin
Format: Article
Language:English
Subjects:
controlled proliferation
drug discovery
gene network engineering
metabolic engineering
tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553
cites cdi_FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553
container_end_page 16
container_issue 1
container_start_page 3
container_title Biotechnology and applied biochemistry
container_volume 39
creator Kelm, Jens M.
Kramer, Beat P.
Gonzalez-Nicolini, Valeria
Ley, Bettina
Fussenegger, Martin
description In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life‐ and material‐science communities. Recent advances in tissue engineering, gene therapy, gene‐function analysis, animal‐free drug testing, drug discovery, biopharmaceutical manufacturing and cell‐phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype‐modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.
doi_str_mv 10.1042/BA20030124
format article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1042_BA20030124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BAB659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553</originalsourceid><addsrcrecordid>eNp9kFFPwjAQxxujiYi--An6bBy2a7d2voFBRIlGRHlcuvZGimOQdiD79o7M6JtPd7n7_S65P0KXlPQo4eHNoB8SwggN-RHqUC5IIAXnx6hDpIwCHlF2is68XxJCpJBhB9XT4cd4OL_Fb3UJbmHB43WOV1a7dWW93wI24O2ivMY761SBK6dKb7a6susSq9JgZZZbX6msgHa3gBIw7DcOvD8w-dphB4epU5XdAV6BsdqWcI5OclV4uPipXfR-P5zdPQSTl9H4rj8JNI1YEiQ0TqiJjeEqA8GUjBVorYnINDV5IoELoTSLGdUhTzIiIaIQ5iwzPOMsilgXXbV3m5e8d5CnG2dXytUpJekhtPQvtAbutfCXLaD-h2zaQRwljRC0gvUV7H8F5T7TWDARpfPnUfoq52z6RB_TGfsG8LF-WQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine</title><source>Wiley</source><creator>Kelm, Jens M. ; Kramer, Beat P. ; Gonzalez-Nicolini, Valeria ; Ley, Bettina ; Fussenegger, Martin</creator><creatorcontrib>Kelm, Jens M. ; Kramer, Beat P. ; Gonzalez-Nicolini, Valeria ; Ley, Bettina ; Fussenegger, Martin</creatorcontrib><description>In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life‐ and material‐science communities. Recent advances in tissue engineering, gene therapy, gene‐function analysis, animal‐free drug testing, drug discovery, biopharmaceutical manufacturing and cell‐phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype‐modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.</description><identifier>ISSN: 0885-4513</identifier><identifier>EISSN: 1470-8744</identifier><identifier>DOI: 10.1042/BA20030124</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>controlled proliferation ; drug discovery ; gene network engineering ; metabolic engineering ; tissue engineering</subject><ispartof>Biotechnology and applied biochemistry, 2004-02, Vol.39 (1), p.3-16</ispartof><rights>2004 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553</citedby><cites>FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kelm, Jens M.</creatorcontrib><creatorcontrib>Kramer, Beat P.</creatorcontrib><creatorcontrib>Gonzalez-Nicolini, Valeria</creatorcontrib><creatorcontrib>Ley, Bettina</creatorcontrib><creatorcontrib>Fussenegger, Martin</creatorcontrib><title>REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine</title><title>Biotechnology and applied biochemistry</title><description>In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life‐ and material‐science communities. Recent advances in tissue engineering, gene therapy, gene‐function analysis, animal‐free drug testing, drug discovery, biopharmaceutical manufacturing and cell‐phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype‐modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.</description><subject>controlled proliferation</subject><subject>drug discovery</subject><subject>gene network engineering</subject><subject>metabolic engineering</subject><subject>tissue engineering</subject><issn>0885-4513</issn><issn>1470-8744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kFFPwjAQxxujiYi--An6bBy2a7d2voFBRIlGRHlcuvZGimOQdiD79o7M6JtPd7n7_S65P0KXlPQo4eHNoB8SwggN-RHqUC5IIAXnx6hDpIwCHlF2is68XxJCpJBhB9XT4cd4OL_Fb3UJbmHB43WOV1a7dWW93wI24O2ivMY761SBK6dKb7a6susSq9JgZZZbX6msgHa3gBIw7DcOvD8w-dphB4epU5XdAV6BsdqWcI5OclV4uPipXfR-P5zdPQSTl9H4rj8JNI1YEiQ0TqiJjeEqA8GUjBVorYnINDV5IoELoTSLGdUhTzIiIaIQ5iwzPOMsilgXXbV3m5e8d5CnG2dXytUpJekhtPQvtAbutfCXLaD-h2zaQRwljRC0gvUV7H8F5T7TWDARpfPnUfoq52z6RB_TGfsG8LF-WQ</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Kelm, Jens M.</creator><creator>Kramer, Beat P.</creator><creator>Gonzalez-Nicolini, Valeria</creator><creator>Ley, Bettina</creator><creator>Fussenegger, Martin</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200402</creationdate><title>REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine</title><author>Kelm, Jens M. ; Kramer, Beat P. ; Gonzalez-Nicolini, Valeria ; Ley, Bettina ; Fussenegger, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>controlled proliferation</topic><topic>drug discovery</topic><topic>gene network engineering</topic><topic>metabolic engineering</topic><topic>tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelm, Jens M.</creatorcontrib><creatorcontrib>Kramer, Beat P.</creatorcontrib><creatorcontrib>Gonzalez-Nicolini, Valeria</creatorcontrib><creatorcontrib>Ley, Bettina</creatorcontrib><creatorcontrib>Fussenegger, Martin</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Biotechnology and applied biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelm, Jens M.</au><au>Kramer, Beat P.</au><au>Gonzalez-Nicolini, Valeria</au><au>Ley, Bettina</au><au>Fussenegger, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine</atitle><jtitle>Biotechnology and applied biochemistry</jtitle><date>2004-02</date><risdate>2004</risdate><volume>39</volume><issue>1</issue><spage>3</spage><epage>16</epage><pages>3-16</pages><issn>0885-4513</issn><eissn>1470-8744</eissn><abstract>In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life‐ and material‐science communities. Recent advances in tissue engineering, gene therapy, gene‐function analysis, animal‐free drug testing, drug discovery, biopharmaceutical manufacturing and cell‐phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype‐modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1042/BA20030124</doi><tpages>14</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0885-4513
ispartof Biotechnology and applied biochemistry, 2004-02, Vol.39 (1), p.3-16
issn 0885-4513
1470-8744
language eng
recordid cdi_crossref_primary_10_1042_BA20030124
source Wiley
subjects controlled proliferation
drug discovery
gene network engineering
metabolic engineering
tissue engineering
title REVIEW: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T00%3A39%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=REVIEW:%20Synergies%20of%20microtissue%20design,%20viral%20transduction%20and%20adjustable%20transgene%20expression%20for%20regenerative%20medicine&rft.jtitle=Biotechnology%20and%20applied%20biochemistry&rft.au=Kelm,%20Jens%20M.&rft.date=2004-02&rft.volume=39&rft.issue=1&rft.spage=3&rft.epage=16&rft.pages=3-16&rft.issn=0885-4513&rft.eissn=1470-8744&rft_id=info:doi/10.1042/BA20030124&rft_dat=%3Cwiley_cross%3EBAB659%3C/wiley_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1539-91691d6dd4abe73a86aeccc07bc1df98e477ac3631c249b08e51e2f3bd4b43553%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true