MicroRNA biosensing through spectral interferometry-based surface plasmon resonance using telecommunication wavelength

The polarisation maintaining (PM) fibre constructed the spectral interferometry-based surface plasmon resonance to detect the very small molecule micro ribonucleic acid (miRNA) with a big biological impact on cancer diagnosis. Other than the linear polariser and birefringence crystal in the input of...

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Bibliographic Details
Published in:Electronics letters 2016-06, Vol.52 (13), p.1096-1098
Main Authors: Hsu, S.-H, Lin, C.-Y, Tuan, C.-T, Chang, C.-C
Format: Article
Language:English
Subjects:
Biomedical technology
biosensors
birefringence
birefringence crystal
cancer diagnosis
Controllers
Diagnosis
dynamic‐range fringes
Electronics
infrared spectra
light injection
linear polariser
low‐coherence telecommunication source
microRNA biosensing
miRNA‐21 sequence
molecular biophysics
optical spectrum analysis
Plasmons
PM fibres
polarisation controller
polarisation maintaining fibre
polarisation state
Ribonucleic acids
RNA
small molecule microribonucleic acid
Spectra
spectral interferometry‐based surface plasmon resonance
surface plasmon resonance
telecommunication wavelength
Telecommunications
traditional spectral interferometry
transverse magnetic polarised magnitudes
ultraviolet spectra
visible spectra
Wavelengths
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Summary:The polarisation maintaining (PM) fibre constructed the spectral interferometry-based surface plasmon resonance to detect the very small molecule micro ribonucleic acid (miRNA) with a big biological impact on cancer diagnosis. Other than the linear polariser and birefringence crystal in the input of the traditional spectral interferometry, the polarisation controller was simply placed on the injected light to control the transverse electric and transverse magnetic polarised magnitudes through the stable polarisation state of PM fibres for distinct dynamic-range fringes on the optical spectrum analyser (OSA). Owing to the high precision and stability control of operating wavelengths in optical fibre communications, the low-coherence telecommunication source was utilised to detect 21-mer deoxyribonucleic acid which changed U to T according the miRNA-21 sequence. The sensitivity with probing was showing 0.065 nm/(μg/ml), which implied the resolution as 0.3 μg/ml under the 0.02 nm wavelength accuracy on OSA.
ISSN:0013-5194
1350-911X
1350-911X
DOI:10.1049/el.2015.4407