Synthesis and characterisation of liposomal doxorubicin with loaded gold nanoparticles

• Published in: IET nanobiotechnology 2018-09, Vol.12 (6), p.846-849
• Main Authors: Karimi Zarchi, Ali Akbar, Amini, Seyed Mohamad, Salimi, Ali, Kharazi, Sharmin
• Format: Article
• Language: English
• Subjects: active loading technique; cancer; cancer treatment; crystal growth from solution; Doxorubicin - administration & dosage; Doxorubicin - analogs & derivatives; Doxorubicin - chemical synthesis; Doxorubicin - chemistry; Doxorubicin - pharmacokinetics; doxorubicin chemotherapy; doxorubicin loading efficiency; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Compounding - methods; drug delivery systems; Drug Liberation; drugs; GNP‐loaded liposomes; gold; Gold - chemistry; gold nanoparticles; gold‐loaded liposomes; Humans; hydrodynamic diameter; Hydrodynamics; lipid bilayers; liposomal doxorubicin; liposomal formulation; Liposomes - chemical synthesis; Liposomes - chemistry; Liposomes - pharmacokinetics; Metal Nanoparticles - chemistry; multifunctional liposomes; nanofabrication; nanomedicine; nanoparticles; Particle Size; passive loading techniques; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacokinetics; Research Article; Spectrophotometry, Ultraviolet
• ISSN: 1751-8741; 1751-875X; 1751-875X
• DOI: 10.1049/iet-nbt.2017.0321

Developing nanostructures for cancer treatment is growing significantly. Liposomal doxorubicin is a drug that is used in the clinic and represents a lot of benefits over doxorubicin. The development of multifunctional liposomes with different cancer treatment capability enables broader applications of doxorubicin chemotherapy. Many efforts were carried to prepare more effective liposomal formulation through loading gold nanoparticles (GNPs) in the formulation. Here, GNPs with an average size of 6 nm were loaded in liposomal formulation alongside doxorubicin. The hydrodynamic diameter of final formulation was 177.3 ± 33.9 nm that in comparison with liposomes without GNPs (112.5 ± 10.3 nm), GNPs-loaded liposomes showed the bigger hydrodynamic diameter. GNPs-loaded liposomes are slightly positively charged (4.4 ± 1.1 mV), while liposomes without loading the GNPs were negatively charged (−18.5 ± 1.6 mV). Doxorubicin was loaded in this formulation through active loading technique. Doxorubicin loading efficiency in gold-loaded liposomes is slightly lesser than liposomes without GNPs, but still considerably high in comparison to passive loading techniques.