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Synergistic evaluation of AgO 2 nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro-pathogenic E. coli
The silver oxide nanoparticles (AgO -NPs) were synthesised using silver foil as a new precursor in wet chemical method. X-ray diffraction analysis shows crystallographic structures of AgO -NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy...
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| Published in: | IET nanobiotechnology 2019-06, Vol.13 (4), p.435-440 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c1139-b271f09fe621bf3af75b2edee8049f8ad59021c9cb3243b4690c42c312f91bea3 |
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| creator | Sajjad, Shamaila Uzair, Bushra Shaukat, Anum Jamshed, Madiha Leghari, Sajjad Ahmed Khan Ismail, Muhammad Mansoor, Qaiser |
| description | The silver oxide nanoparticles (AgO
-NPs) were synthesised using silver foil as a new precursor in wet chemical method. X-ray diffraction analysis shows crystallographic structures of AgO
-NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy analysis clearly shows the random distribution of spherical-shaped nanoparticles. Energy dispersive X-ray analysis confirmed the purity of the samples as it shows no impurity element. Fourier transforms infra-red analysis confirmed the formation of AgO
-NPs with the presence of Ag-O-Ag stretching bond. All the techniques also confirmed the loading of ceftriaxone drug on the surface of AgO
-NPs. This study also described the effect of AgO
-NPs having synergistic activity with
lactam antibiotic i.e. ceftriaxone against ESBL generating
. Among isolated strains of
, 60.0% were found to be ESBL producer. The synergistic activities of AgO
-NPs with ceftriaxone suggest that these combinations are effective against MDR-ESBL
strains as evident by increase in zone sizes. The present study observed rise in MDR-ESBL
with polymorphism of blaCTXM and blaSHV causing UTI infections in Pakistani population. The antibiotic and AgO
-NPs synergistic effect can be used as an efficient approach to combat uro-pathogenic infections. |
| doi_str_mv | 10.1049/iet-nbt.2018.5415 |
| format | article |
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-NPs) were synthesised using silver foil as a new precursor in wet chemical method. X-ray diffraction analysis shows crystallographic structures of AgO
-NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy analysis clearly shows the random distribution of spherical-shaped nanoparticles. Energy dispersive X-ray analysis confirmed the purity of the samples as it shows no impurity element. Fourier transforms infra-red analysis confirmed the formation of AgO
-NPs with the presence of Ag-O-Ag stretching bond. All the techniques also confirmed the loading of ceftriaxone drug on the surface of AgO
-NPs. This study also described the effect of AgO
-NPs having synergistic activity with
lactam antibiotic i.e. ceftriaxone against ESBL generating
. Among isolated strains of
, 60.0% were found to be ESBL producer. The synergistic activities of AgO
-NPs with ceftriaxone suggest that these combinations are effective against MDR-ESBL
strains as evident by increase in zone sizes. The present study observed rise in MDR-ESBL
with polymorphism of blaCTXM and blaSHV causing UTI infections in Pakistani population. The antibiotic and AgO
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-NPs) were synthesised using silver foil as a new precursor in wet chemical method. X-ray diffraction analysis shows crystallographic structures of AgO
-NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy analysis clearly shows the random distribution of spherical-shaped nanoparticles. Energy dispersive X-ray analysis confirmed the purity of the samples as it shows no impurity element. Fourier transforms infra-red analysis confirmed the formation of AgO
-NPs with the presence of Ag-O-Ag stretching bond. All the techniques also confirmed the loading of ceftriaxone drug on the surface of AgO
-NPs. This study also described the effect of AgO
-NPs having synergistic activity with
lactam antibiotic i.e. ceftriaxone against ESBL generating
. Among isolated strains of
, 60.0% were found to be ESBL producer. The synergistic activities of AgO
-NPs with ceftriaxone suggest that these combinations are effective against MDR-ESBL
strains as evident by increase in zone sizes. The present study observed rise in MDR-ESBL
with polymorphism of blaCTXM and blaSHV causing UTI infections in Pakistani population. The antibiotic and AgO
-NPs synergistic effect can be used as an efficient approach to combat uro-pathogenic infections.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Ceftriaxone - chemistry</subject><subject>Ceftriaxone - pharmacology</subject><subject>Drug Synergism</subject><subject>Escherichia coli - drug effects</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Oxides - chemistry</subject><subject>Oxides - pharmacology</subject><subject>Silver Compounds - chemistry</subject><subject>Silver Compounds - pharmacology</subject><issn>1751-8741</issn><issn>1751-875X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo9kE1u2zAQRomgRf6aA2RTzAXkcEjRkpap4dQFXGThpMhOIClSZqGQAkkn8Wl61UpIm9UMMN-bGTxCrpEukJbNjTO58CovGMV6IUoUJ-QcK4FFXYmnTx99iWfkIqXflAoheH1KzjhihVXZnJM_u6M3sXcpOw3mRQ4HmV3wECzc9vfAwEsfRhmn8WASvLq8B21sjk6-BW9A9tL5lGH18PQTpO9ADXK3-QW98VN8DMll92Jgvfu2hTGG7qCd70EPzjstB0g5zvx87jGGYpR5HyZ0-mW9AB0G94V8tnJI5upfvSSPd-uH1abY3n__sbrdFhqRN4ViFVraWLNkqCyXthKKmc6YevJka9mJhjLUjVaclVyVy4bqkmmOzDaojOSXBN_36hhSisa2Y3TPMh5bpO0su51kt5PsdpbdzrIn5us7Mx7Us-k-iP92-V99iH8T</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Sajjad, Shamaila</creator><creator>Uzair, Bushra</creator><creator>Shaukat, Anum</creator><creator>Jamshed, Madiha</creator><creator>Leghari, Sajjad Ahmed Khan</creator><creator>Ismail, Muhammad</creator><creator>Mansoor, Qaiser</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201906</creationdate><title>Synergistic evaluation of AgO 2 nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro-pathogenic E. coli</title><author>Sajjad, Shamaila ; Uzair, Bushra ; Shaukat, Anum ; Jamshed, Madiha ; Leghari, Sajjad Ahmed Khan ; Ismail, Muhammad ; Mansoor, Qaiser</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1139-b271f09fe621bf3af75b2edee8049f8ad59021c9cb3243b4690c42c312f91bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Ceftriaxone - chemistry</topic><topic>Ceftriaxone - pharmacology</topic><topic>Drug Synergism</topic><topic>Escherichia coli - drug effects</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Oxides - chemistry</topic><topic>Oxides - pharmacology</topic><topic>Silver Compounds - chemistry</topic><topic>Silver Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sajjad, Shamaila</creatorcontrib><creatorcontrib>Uzair, Bushra</creatorcontrib><creatorcontrib>Shaukat, Anum</creatorcontrib><creatorcontrib>Jamshed, Madiha</creatorcontrib><creatorcontrib>Leghari, Sajjad Ahmed Khan</creatorcontrib><creatorcontrib>Ismail, Muhammad</creatorcontrib><creatorcontrib>Mansoor, Qaiser</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>IET nanobiotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sajjad, Shamaila</au><au>Uzair, Bushra</au><au>Shaukat, Anum</au><au>Jamshed, Madiha</au><au>Leghari, Sajjad Ahmed Khan</au><au>Ismail, Muhammad</au><au>Mansoor, Qaiser</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic evaluation of AgO 2 nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro-pathogenic E. coli</atitle><jtitle>IET nanobiotechnology</jtitle><addtitle>IET Nanobiotechnol</addtitle><date>2019-06</date><risdate>2019</risdate><volume>13</volume><issue>4</issue><spage>435</spage><epage>440</epage><pages>435-440</pages><issn>1751-8741</issn><eissn>1751-875X</eissn><abstract>The silver oxide nanoparticles (AgO
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-NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy analysis clearly shows the random distribution of spherical-shaped nanoparticles. Energy dispersive X-ray analysis confirmed the purity of the samples as it shows no impurity element. Fourier transforms infra-red analysis confirmed the formation of AgO
-NPs with the presence of Ag-O-Ag stretching bond. All the techniques also confirmed the loading of ceftriaxone drug on the surface of AgO
-NPs. This study also described the effect of AgO
-NPs having synergistic activity with
lactam antibiotic i.e. ceftriaxone against ESBL generating
. Among isolated strains of
, 60.0% were found to be ESBL producer. The synergistic activities of AgO
-NPs with ceftriaxone suggest that these combinations are effective against MDR-ESBL
strains as evident by increase in zone sizes. The present study observed rise in MDR-ESBL
with polymorphism of blaCTXM and blaSHV causing UTI infections in Pakistani population. The antibiotic and AgO
-NPs synergistic effect can be used as an efficient approach to combat uro-pathogenic infections.</abstract><cop>United States</cop><pmid>31171749</pmid><doi>10.1049/iet-nbt.2018.5415</doi><tpages>6</tpages></addata></record> |
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| ispartof | IET nanobiotechnology, 2019-06, Vol.13 (4), p.435-440 |
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| language | eng |
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| source | IET Digital Library; Wiley Online Library Open Access; PubMed Central |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Ceftriaxone - chemistry Ceftriaxone - pharmacology Drug Synergism Escherichia coli - drug effects Metal Nanoparticles - chemistry Microbial Sensitivity Tests Oxides - chemistry Oxides - pharmacology Silver Compounds - chemistry Silver Compounds - pharmacology |
| title | Synergistic evaluation of AgO 2 nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro-pathogenic E. coli |
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