Late endocrine, metabolic and skeletal sequelae following treatment of childhood cancer

With an ever increasing adult population of childhood cancer survivors there is a need to focus on the late effects of cancer therapy. It is essential that, after discharge from the paediatric oncologists, the patients are not lost from the health system but are under continued surveillance with acc...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical endocrinology & metabolism 2002-06, Vol.16 (2), p.335-348
Main Authors: Gleeson, Helena K., Darzy, Ken, Shalet, Stephen M.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
bone
Bone Diseases - etiology
Cardiovascular Diseases - etiology
cardiovascular risk
Child
Endocrine System Diseases - etiology
Gonadal Steroid Hormones - administration & dosage
growth hormone
Human Growth Hormone - deficiency
Humans
neoplasms
Neoplasms - therapy
parathyroid
Radiotherapy - adverse effects
thyroid
Thyroid Diseases - etiology
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Summary:With an ever increasing adult population of childhood cancer survivors there is a need to focus on the late effects of cancer therapy. It is essential that, after discharge from the paediatric oncologists, the patients are not lost from the health system but are under continued surveillance with access to the appropriate physicians. Endocrine and metabolic consequences may affect a patient's life both soon after cancer treatment and also for many years in the future. In this review we consider the following potential problems: growth hormone deficiency and replacement in adulthood, cardiovascular risk factors, osteopaenia, thyroid and parathyroid dysfunction.
ISSN:1521-690X
1878-1594
DOI:10.1053/beem.2002.0201