Advances with analgesics and NSAIDs for the treatment of spinal disorders

One of the major developments with regard to chronic non-malignant pain in these last few years has been a better understanding of the mechanisms that act to maintain pain, while inferences about the pathophysiology have facilitated therapeutic decision-making. This chapter reviews the strength of e...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2002-01, Vol.16 (1), p.105-121
Main Authors: Desmeules, J.A., Cedraschi, C., Piguet, V., Allaz, A.-F., Dayer, Pierre
Format: Article
Language:English
Subjects:
Acute Disease
analgesics
Analgesics - therapeutic use
anti-depressants
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Back Pain - drug therapy
Back Pain - etiology
Chronic Disease
compliance
COX-2 selective agents
Humans
low back pain
non-steroidal anti-inflammatory agents
NSAIDs
opioids
Spinal Diseases - complications
Spinal Diseases - drug therapy
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Summary:One of the major developments with regard to chronic non-malignant pain in these last few years has been a better understanding of the mechanisms that act to maintain pain, while inferences about the pathophysiology have facilitated therapeutic decision-making. This chapter reviews the strength of evidence for the therapeutic effect of pharmacological symptomatic approaches using non-steroidal anti-inflammatory agents, opioids and co-analgesics in acute and chronic back pain with an emphasis on the results of randomized controlled trials as well as on the need for long-term comparative trials of drug efficacy, toxicity and compliance.
ISSN:1521-6942
1532-1770
DOI:10.1053/berh.2002.0209