Lack of association between childhood stroke after varicella and human leukocyte antigen (HLA)-B51

Human leukocyte antigen (HLA)-B51 has been suggested as an immunogenetic marker for a genetic predisposition to vascular occlusion in response to an immunological stimulus. Varicella has been reported to be a possible risk factor for stroke.We performed DNA-based HLA typing in 11 young patients (mea...

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Bibliographic Details
Published in:European journal of paediatric neurology 2001-11, Vol.5 (6), p.259-260
Main Authors: Kluger, Gerhard, Hubmann, Michael, Vogler, Lukas, Berz, Karolin
Format: Article
Language:English
Subjects:
Chickenpox - immunology
Child
Child, Preschool
Female
HLA (human leukocyte antigen), Stroke, Varicella, Children
HLA Antigens - immunology
Humans
Male
Protein C - metabolism
Protein S - metabolism
Retrospective Studies
Stroke - immunology
Stroke - metabolism
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Summary:Human leukocyte antigen (HLA)-B51 has been suggested as an immunogenetic marker for a genetic predisposition to vascular occlusion in response to an immunological stimulus. Varicella has been reported to be a possible risk factor for stroke.We performed DNA-based HLA typing in 11 young patients (mean age: 5.2 years) with unexplained ischaemic stroke. In eight of them varicella had occurred before their stroke. HLA-B51 was negative in all 11 patients and we did not find any significant accumulation of other HLA-subgroups.Our study does not support an association between susceptibility to stroke after varicella and HLA-B51.
ISSN:1090-3798
1532-2130
DOI:10.1053/ejpn.2001.0526