The utility of mitotic index, oestrogen receptor and Ki-67 measurements in the creation of novel prognostic indices fornode-negative breast cancer

Introduction:Prognostic factors can be useful to identify node-negative patients at increased risk of relapse who should receive adjuvant treatment. In the past, oestrogen receptor status and mitotic index have been shown to be significant predictors of prognosis. Different techniques for the measur...

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Bibliographic Details
Published in:European journal of surgical oncology 1999-08, Vol.25 (4), p.356-363
Main Authors: Clahsen, P.C., van de Velde, C.J.H., Duval, C., Pallud, C., Mandard, A.- M., Delobelle-Deroide, A., van den Broek, L., van de Vijver, M.J.
Format: Article
Language:English
Subjects:
breast cancer
Ki-67
oestrogen receptor
prognosis
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Summary:Introduction:Prognostic factors can be useful to identify node-negative patients at increased risk of relapse who should receive adjuvant treatment. In the past, oestrogen receptor status and mitotic index have been shown to be significant predictors of prognosis. Different techniques for the measurement of these prognostic factors are available.Methods:Paraffin-embedded tumour specimens from 441 pre-menopausal patients with node-negative breast cancer who were previously randomized onto a trial comparing peri-operative chemotherapy with no further therapy were studied. Oestrogen receptor status was determined by the classical biochemical assay and by immunohistochemistry (ER-IA). Mitotic index was assessed by counting the number of mitoses and by calculating the percentage of tumour cells positively staining for the antibody Ki-67.Results:There was a good correlation between ER-IA and the biochemical ER-assay (P
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.1999.0657