Desmoplastic small round cell tumour of the pleura:a case report with further cytogenetic andultrastructural evidence of «mesothelioblastemic» origin

A typical case of desmoplastic small round cell tumour of the pleura in a 25-year-old man is described. In addition to the typical histological and immunohistological findings, the EWS-WT1 fusion product was also observed. Ultrastructurally, some tumour cells displayed intracytoplasmic neolumina, wi...

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Bibliographic Details
Published in:European journal of surgical oncology 1999-12, Vol.25 (6), p.633-634
Main Authors: Sápi, Z, Szentirmay, Z, Orosz, Z
Format: Article
Language:English
Subjects:
desmoplastic small round cell tumour
EWS-WT1 fusion gene
intracytoplasmic neolumina
pleura
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Summary:A typical case of desmoplastic small round cell tumour of the pleura in a 25-year-old man is described. In addition to the typical histological and immunohistological findings, the EWS-WT1 fusion product was also observed. Ultrastructurally, some tumour cells displayed intracytoplasmic neolumina, with short microvilli characteristic of submesothelial cells. These findings support the theory of a splanchnopleuric intraembryonic mesodermal, «mesothelioblastemic» origin, both morphologically and cytogenetically.
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.1999.0721