A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity

Aim Our experience of pre-operative intraarterial (i.a.) vs intravenous (i.v.) infusion of cisplatinum (CDP) in a multiagent neo-adjuvant chemotherapy for osteosarcoma of the extremity is reported.Methods Two successive randomized studies were performed. In the first, pre-operatively, CDP i.a. vs CD...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2001-02, Vol.27 (1), p.98-104
Main Authors: Bacci, G., Ferrari, S., Tienghi, A., Bertoni, F., Mercuri, M., Longhi, A., Fiorentini, G., Forni, C., Bacchini, P., Rimondini, S., De Giorgi, U., Picci, P.
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Bone Neoplasms - drug therapy
Bone Neoplasms - mortality
Bone Neoplasms - surgery
Chemotherapy
Chemotherapy, Adjuvant
cisplatin
Cisplatin - administration & dosage
Cisplatin - adverse effects
Combined Modality Therapy
Disease-Free Survival
Diseases of the osteoarticular system
Doxorubicin - administration & dosage
Extremities
Female
Humans
Ifosfamide - administration & dosage
Infusions, Intra-Arterial
Infusions, Intravenous
intra
Male
Medical sciences
Methotrexate - administration & dosage
neo-adjuvant chemotherapy
Neoplasm Recurrence, Local
osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - mortality
Osteosarcoma - surgery
Pharmacology. Drug treatments
Survival Rate
Tumors of striated muscle and skeleton
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim Our experience of pre-operative intraarterial (i.a.) vs intravenous (i.v.) infusion of cisplatinum (CDP) in a multiagent neo-adjuvant chemotherapy for osteosarcoma of the extremity is reported.Methods Two successive randomized studies were performed. In the first, pre-operatively, CDP i.a. vs CDP i.v. was applied in combination with high-dose methotrexate (HDMTX) and adriamycin (ADM) within a three-drug regimen. In the second, a combination of HDMTX, ADM and IFO, within a four-drug regimen was tested. Results The rate of responses to chemotherapy (tumour necrosis ≥90%) was significantly higher (P
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.2000.1056