Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix

We have previously demonstrated a strong relationship between loss of heterozygosity (LOH) at chromosome 11q23.3 and the presence of extensive tumor plugs in lymphvascular spaces (LVS) in stage 1B cervical carcinoma, suggesting that genes at this locus may regulate vasculoinvasion. This study examin...

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Published in:Human pathology 2001-05, Vol.32 (5), p.475-478
Main Authors: O'Sullivan, Maureen J., Rader, Janet S., Gerhard, Daniela S., Li, Yan, Trinkaus, Kathryn M., Gersell, Deborah J., Huettner, Phyllis C.
Format: Article
Language:English
Subjects:
Adult
Aged
allelotyping
Biological and medical sciences
Blood Vessels - pathology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
cervical cancer
Chromosomes, Human, Pair 11
Continental Population Groups
DNA, Neoplasm - analysis
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Loss of Heterozygosity
Lymphatic Metastasis
Medical sciences
metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local
recurrence
Tumors
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - pathology
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Summary:We have previously demonstrated a strong relationship between loss of heterozygosity (LOH) at chromosome 11q23.3 and the presence of extensive tumor plugs in lymphvascular spaces (LVS) in stage 1B cervical carcinoma, suggesting that genes at this locus may regulate vasculoinvasion. This study examined LOH at 11q23.3 in microdissected tumor plugs within LVS and in metastatic foci in lymph nodes (MFLN), as well as corresponding invasive tumor and adjacent cervical intraepithelial neoplasia (CIN) 3 in stage 1B squamous cell carcinoma. Of 49 invasive carcinomas, 38.8% had LOH at 11q23.3. Of 36 tumor plugs in LVS, 39% had LOH at 11q23.3. Twenty percent of 15 MFLN demonstrated LOH at 11q23.3. Patients with LOH at 11q23.3 are significantly more likely to have disease recurrence than patients without LOH at 11q23.3 (P =.02). Of 10 foci of CIN 3, none showed LOH at 11q23.3. Although unlikely to have an impact early in carcinogenesis, tumor-suppressor genes located in the region of 11q23.3 appear to be important in tumor progression, facilitating lymphvascular space invasion and, by inference, spread to lymph nodes in squamous cell carcinoma of the cervix. HUM PATHOL 32:475-478. Copyright © 2001 by W.B. Saunders Company
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2001.24317