Comparison of Nicardipine Versus Esmolol in Attenuating the Hemodynamic Responses to Anesthesia Emergence and Extubation

Objective: The purpose of this study was to compare the effectiveness of intravenous (IV) nicardipine versus esmolol in controlling heart rate (HR) and blood pressure (BP) responses to emergence and extubation. Design: Prospective, randomized, double blind. Setting: University hospital, single insti...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2007-02, Vol.21 (1), p.45-50
Main Authors: Kovac, Anthony L., MD, Masiongale, Amy, SRNA
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - adverse effects
Adrenergic beta-Antagonists - pharmacology
Adult
Anesthesia & Perioperative Care
Anesthesia Recovery Period
Anesthesia, General - methods
blood pressure
Blood Pressure - drug effects
calcium channel blocker
Calcium Channel Blockers - administration & dosage
Calcium Channel Blockers - adverse effects
Calcium Channel Blockers - pharmacology
Critical Care
Double-Blind Method
Elective Surgical Procedures - methods
emergence
esmolol
extubation
Female
heart rate
Heart Rate - drug effects
hemodynamics
Humans
Injections, Intravenous - methods
Intubation, Intratracheal - methods
Male
mean arterial pressure
Middle Aged
nicardipine
Nicardipine - administration & dosage
Nicardipine - adverse effects
Nicardipine - pharmacology
Propanolamines - administration & dosage
Propanolamines - adverse effects
Propanolamines - pharmacology
Prospective Studies
Time Factors
Treatment Outcome
β-blocker
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Description
Summary:Objective: The purpose of this study was to compare the effectiveness of intravenous (IV) nicardipine versus esmolol in controlling heart rate (HR) and blood pressure (BP) responses to emergence and extubation. Design: Prospective, randomized, double blind. Setting: University hospital, single institution. Participants: Twenty-two American Society of Anesthesiologists physical class 1 to 3 adult inpatients scheduled for general anesthesia. Interventions: General endotracheal anesthesia with oxygen/isoflurane and muscle relaxation. At end of surgery, with at least 2 twitches by nerve stimulator and end-tidal isoflurane
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2006.08.005