Synovial Fluid Cytokine Levels in Diagnosis of Indolent Prosthetic Shoulder Joint Infection

Abstract Periprosthetic joint infection is one of the most serious complications associated with arthroplasty surgery and poses great diagnostic difficulty. Traditional diagnostic methods used to diagnosis infection in the lower extremity are less accurate for shoulder prosthetic joint infection due...

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Bibliographic Details
Published in:Seminars in arthroplasty 2017-03, Vol.28 (1), p.30-35
Main Authors: Iannotti, Joseph P., MD, PhD, Mahylis, Jared M., MD, Ricchetti, Eric T., MD
Format: Article
Language:English
Subjects:
Diagnosis
Indolent infection
Orthopedics
P. acnes
Periprosthetic infection
Shoulder arthroplasty
Synovial fluid cytokines
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Summary:Abstract Periprosthetic joint infection is one of the most serious complications associated with arthroplasty surgery and poses great diagnostic difficulty. Traditional diagnostic methods used to diagnosis infection in the lower extremity are less accurate for shoulder prosthetic joint infection due to the indolent nature of the most common pathogen, Propionibacterium acnes. In additional to preoperative lab work and intraoperative tissue cultures, a more recent tool for evaluation of periprostehtic infection has been analysis of synovial fluid for antimicrobial peptides and cytokines. Investigation of synovial biomarkers such as α-defensin and interleukins offers improved ability to more accurately diagnosis prosthetic shoulder joint infection.
ISSN:1045-4527
1558-4437
DOI:10.1053/j.sart.2017.05.007