Severe nonendemic pemphigus foliaceus presenting in the postpartum period

The new onset of pemphigus in the postpartum period is exceedingly rare with only 1 case previously reported in the literature. We describe a 31-year-old woman who developed extensive denudation of her skin shortly after delivering her second child. Histologic examination, immunofluorescence testing...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1999-05, Vol.40 (5), p.845-846
Main Authors: Nousari, Hossein C, Kimyai-Asadi, Arash, Ketabchi, Nooshin, Diaz, Luis A, Anhalt, Grant J
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Autoantigens - analysis
Biological and medical sciences
Bullous diseases of the skin
Cadherins - analysis
Cyclophosphamide - therapeutic use
Dermatology
Desmoglein 1
Female
Fluorescent Antibody Technique, Direct
Glucocorticoids - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Medical sciences
Pemphigus - immunology
Pemphigus - pathology
Plasmapheresis
Precipitin Tests
Prednisone - therapeutic use
Puerperal Disorders - immunology
Puerperal Disorders - pathology
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Summary:The new onset of pemphigus in the postpartum period is exceedingly rare with only 1 case previously reported in the literature. We describe a 31-year-old woman who developed extensive denudation of her skin shortly after delivering her second child. Histologic examination, immunofluorescence testing, and immunoprecipitation with desmoglein 1 confirmed the diagnosis of pemphigus foliaceus. The patient responded to treatment with prednisone, cyclophosphamide, and plasmapheresis. The effect of the postpartum period on the onset and exacerbation of immune-mediated bullous diseases is discussed. (J Am Acad Dermatol 1999;40:845-6.)
ISSN:0190-9622
1097-6787
DOI:10.1053/jd.1999.v40.a95204