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Severe nonendemic pemphigus foliaceus presenting in the postpartum period
The new onset of pemphigus in the postpartum period is exceedingly rare with only 1 case previously reported in the literature. We describe a 31-year-old woman who developed extensive denudation of her skin shortly after delivering her second child. Histologic examination, immunofluorescence testing...
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Published in: | Journal of the American Academy of Dermatology 1999-05, Vol.40 (5), p.845-846 |
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creator | Nousari, Hossein C Kimyai-Asadi, Arash Ketabchi, Nooshin Diaz, Luis A Anhalt, Grant J |
description | The new onset of pemphigus in the postpartum period is exceedingly rare with only 1 case previously reported in the literature. We describe a 31-year-old woman who developed extensive denudation of her skin shortly after delivering her second child. Histologic examination, immunofluorescence testing, and immunoprecipitation with desmoglein 1 confirmed the diagnosis of pemphigus foliaceus. The patient responded to treatment with prednisone, cyclophosphamide, and plasmapheresis. The effect of the postpartum period on the onset and exacerbation of immune-mediated bullous diseases is discussed. (J Am Acad Dermatol 1999;40:845-6.) |
doi_str_mv | 10.1053/jd.1999.v40.a95204 |
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subjects | Adult Anti-Inflammatory Agents - therapeutic use Autoantigens - analysis Biological and medical sciences Bullous diseases of the skin Cadherins - analysis Cyclophosphamide - therapeutic use Dermatology Desmoglein 1 Female Fluorescent Antibody Technique, Direct Glucocorticoids - therapeutic use Humans Immunosuppressive Agents - therapeutic use Medical sciences Pemphigus - immunology Pemphigus - pathology Plasmapheresis Precipitin Tests Prednisone - therapeutic use Puerperal Disorders - immunology Puerperal Disorders - pathology |
title | Severe nonendemic pemphigus foliaceus presenting in the postpartum period |
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