The role of preoperative chemotherapy in the treatment of infantile fibrosarcoma

Infantile fibrosarcoma (IFS) is a rare tumor most often affecting the extremities of infants and young children. Unlike its adult counterpart, IFS has a low potential for metastatic spread, and surgical extirpation alone has therefore resulted in an excellent prognosis. The amputation rate, however,...

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Bibliographic Details
Published in:Journal of pediatric surgery 2000-06, Vol.35 (6), p.880-883
Main Authors: Kurkchubasche, Arlet G., Halvorson, Eric G., Forman, Edwin N., Terek, Richard M., Ferguson, William S.
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Arm
Biological and medical sciences
Combined Modality Therapy
Cyclophosphamide - administration & dosage
Dactinomycin - administration & dosage
Diseases of the osteoarticular system
Fibrosarcoma - congenital
Fibrosarcoma - drug therapy
Fibrosarcoma - surgery
Humans
Infant, Newborn
Infantile fibrosarcoma
limb salvage
Male
Medical sciences
nonrhabdomyosarcoma soft tissue sarcoma
Tumors of striated muscle and skeleton
Vincristine - administration & dosage
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Summary:Infantile fibrosarcoma (IFS) is a rare tumor most often affecting the extremities of infants and young children. Unlike its adult counterpart, IFS has a low potential for metastatic spread, and surgical extirpation alone has therefore resulted in an excellent prognosis. The amputation rate, however, exceeds 50%. The dramatic response in 2 recent cases to preoperative chemotherapy, given in an attempt to avoid amputation, prompted this report and a review of the literature. J Pediatr Surg 35:880-883. Copyright © 2000 by W.B. Saunders Company.
ISSN:0022-3468
1531-5037
DOI:10.1053/jpsu.2000.6871