Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates

The authors report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octreotide, to enhance resolution of the fistula. The authors discuss the mechanism of the occurr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2003-02, Vol.38 (2), p.251-253
Main Authors: Arevalo, R.P., Bullabh, P., Krauss, A.N., Auld, P.A.M., Spigland, Nitsana
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Enterocolitis, Necrotizing - complications
enterocutaneous fistula
Fatal Outcome
Gastrointestinal Agents - adverse effects
Gastrointestinal Agents - therapeutic use
Humans
Hypertension, Pulmonary - chemically induced
Hypoxia - chemically induced
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - chemically induced
Intestinal Fistula - drug therapy
Intestinal Fistula - etiology
Male
Medical sciences
Octreotide - adverse effects
Octreotide - therapeutic use
Pharmacology. Drug treatments
pulmonary hypertension
Somatostatin
Toxicity: cardiovascular system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The authors report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octreotide, to enhance resolution of the fistula. The authors discuss the mechanism of the occurrence of this complication and recommend caution of its use in high-risk premature neonates. J Pediatr Surg 38:251-253. Copyright 2003, Elsevier Science (USA). All rights reserved.
ISSN:0022-3468
1531-5037
DOI:10.1053/jpsu.2003.50056