Gln27Glu and Arg16Gly polymorphisms of the β2-adrenergic receptor gene are not associated with obesity in Japanese men

The β2-adrenergic receptor (β2AR), β3AR, or uncoupling protein 1 (UCP1) may play a pathogenic role in obesity. In Swedish Caucasians, a polymorphism at codon 27 (Gln27Glu) of the β2AR gene was shown to be associated with obesity, but no such association was shown for a polymorphism of codon 16 (Arg1...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2000-09, Vol.49 (9), p.1215-1218
Main Authors: Hayakawa, Tetsuo, Nagai, Yukihiro, Kahara, Toshio, Yamashita, Haruhisa, Takamura, Toshinari, Abe, Toshio, Nomura, Gakuji, Kobayashi, Ken-ichi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Metabolic diseases
Obesity
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Summary:The β2-adrenergic receptor (β2AR), β3AR, or uncoupling protein 1 (UCP1) may play a pathogenic role in obesity. In Swedish Caucasians, a polymorphism at codon 27 (Gln27Glu) of the β2AR gene was shown to be associated with obesity, but no such association was shown for a polymorphism of codon 16 (Arg16Gly). Thus, we investigated whether these polymorphisms contribute to obesity in 210 Japanese men. The frequencies of the Gln27Glu and Arg16Gly polymorphisms were 0.05 and 0.48, respectively, and there was no association with obesity. A strong linkage disequilibrium between the Gln27Glu and Arg16Gly polymorphisms was shown, but there was no apparent additive effect on the clinical or metabolic characteristics. Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the β2AR gene are not a major contributing factor to obesity in Japanese men.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2000.8622