Case report: Somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma

A 54-year-old woman presented with extremely fluctuating and symptomatic blood glucose levels. Very high levels of somatostatin and low levels of insulin, C-peptide, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) in peripheral blood were constantly present. A benign somatostat...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2002-09, Vol.51 (9), p.1180-1183
Main Authors: Gregersen, Gunnar, Holst, J.J., Trankjaer, A., Stadil, F., Mogensen, Anne M.
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Female
Humans
Hyperglycemia - etiology
Hypoglycemia - etiology
Middle Aged
Multiple Endocrine Neoplasia - pathology
Ovarian Neoplasms - metabolism
Somatostatin - biosynthesis
Somatostatinoma - pathology
Teratoma - complications
Teratoma - metabolism
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Summary:A 54-year-old woman presented with extremely fluctuating and symptomatic blood glucose levels. Very high levels of somatostatin and low levels of insulin, C-peptide, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) in peripheral blood were constantly present. A benign somatostatinoma was localized by meta-iodobenzyl guanidine iodine 123 (MIBG-I123) scintigraphy and succesfully removed encapsulated in an ovarian teratoma. The patient made a complete recovery. The case described is unique with regard to clinical symptomatology and anatomic localization of the tumor.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2002.34710