Plasma fatty acids response to central volume expansion in salt-sensitive hypertension

The purpose of the present study was to investigate the possible regulation of plasma fatty acids by an acute isotonic-isooncotic central volume expansion. We measured the levels of nonesterified fatty acids (NEFA) in plasma from 12 essential hypertensive patients subjected to water immersion (WI)....

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2003-04, Vol.52 (4), p.508-513
Main Authors: Coruzzi, Paolo, Brambilla, Lorenzo, Brambilla, Valerio, Gualerzi, Massimo, Parati, Gianfranco, Di Rienzo, Marco, Zanardi, Emanuela, Novarini, Almerico
Format: Article
Language:English
Subjects:
Adult
Aldosterone - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Volume - physiology
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Creatinine - blood
Fatty Acids, Nonesterified - blood
Female
Humans
Hypertension - blood
Hypertension - chemically induced
Immersion - physiopathology
Insulin - blood
Male
Medical sciences
Middle Aged
Palmitic Acids - blood
Renin - blood
Sodium - urine
Sodium Chloride
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Summary:The purpose of the present study was to investigate the possible regulation of plasma fatty acids by an acute isotonic-isooncotic central volume expansion. We measured the levels of nonesterified fatty acids (NEFA) in plasma from 12 essential hypertensive patients subjected to water immersion (WI). Central hypervolemia by WI over 2 hours caused the levels of most NEFA to increase, concomitantly with a marked natriuretic and kaliuretic response. With respect to baseline values, serum insulin levels did not change during WI, while there was a profound suppression of plasma renin activity (PRA) and plasma aldosterone. In addition, when individual NEFA percent increase was expressed as a function of salt-sensitivity index (calculated as the change in mean arterial pressure [MAP] divided by the change in urinary sodium excretion rate), a greater percent increase in stearic acid (r =.72, P
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2003.50074