Prognostic factors in diffuse malignant pleural mesothelioma: effects of pretreatment clinical and laboratory characteristics

The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with ch...

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Bibliographic Details
Published in:Respiratory medicine 2001-10, Vol.95 (10), p.829-835
Main Authors: METINTAS, M., METINTAS, S., UCGUN, I., GIBBS, A.R., HARMANCI, E., ALATAS, F., ERGINEL, S., TEL, N., PASAOGLU, O.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Asbestos
asbestos exposure
Biological and medical sciences
Chest Pain - etiology
Dyspnea - etiology
Environmental Exposure
Female
histopathology
Humans
Lung Neoplasms - complications
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Medical sciences
mesothelioma
Mesothelioma - complications
Mesothelioma - mortality
Mesothelioma - pathology
Middle Aged
Pneumology
Prognosis
Proportional Hazards Models
Regression Analysis
Sex Factors
Smoking - adverse effects
Survival Rate
Time Factors
treatment
Tumors of the respiratory system and mediastinum
Weight Loss
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Summary:The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy, while 41 who had refused chemoimmunotherapy received supportive therapy alone. The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology, asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage). Univariate analysis showed that patients with age ≥75 years, male gender, smoking history, advanced stages above stage I disease, KPS
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.2001.1178