Loading…
A novel derivative pentacyclic triterpene and ω 3 fatty acid [Lupeol-EPA] in relation to lysosomal enzymes glycoproteins and collagen in adjuvant induced arthritis in rats
Adjuvant induced arthritis (AIA) is accompanied by marked changes in the levels of lysosomal enzymes, glycoproteins and metabolic turnover of collagen. The role of a pentacyclic triterpene and eicosapentaenoic acid (EPA) derivative – Lupeol-EPA (50 mg/kg body weight – orally) was tested in vivo in r...
Saved in:
Published in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2001-02, Vol.64 (2), p.81-85 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Adjuvant induced arthritis (AIA) is accompanied by marked changes in the levels of lysosomal enzymes, glycoproteins and metabolic turnover of collagen. The role of a pentacyclic triterpene and eicosapentaenoic acid (EPA) derivative – Lupeol-EPA (50 mg/kg body weight – orally) was tested in vivo in rats. The increased activities of lysosomal enzymes and glycoproteins associated with decreased collagen in arthritic animals were significantly altered to nearly that of controls. Indomethacin (3 mg/kg body weight) was used as a reference compound. The therapeutic usefulness of Lupeol-EPA derivative in inflammatory conditions is attractive and deserves further work in this direction. |
---|---|
ISSN: | 0952-3278 1532-2823 |
DOI: | 10.1054/plef.2001.0245 |