Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy

Abstract A one-pot synthesis of new 3-benzylphthalide derivatives was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with methyl 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-ni...

Full description

Saved in:
Bibliographic Details
Published in:Synlett 2021-02, Vol.32 (3), p.283-286
Main Authors: Ibrahimi, Maroua, Khoumeri, Omar, Abderrahim, Raoudha, Terme, Thierry, Vanelle, Patrice
Format: Article
Language:English
Subjects:
letter
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A one-pot synthesis of new 3-benzylphthalide derivatives was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with methyl 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3 H )-one products in moderate to good yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1290-8349