Stereoselective Synthesis of Polyfunctionalized Nitrones through Conjugate Addition of α-Halo Hydrazones to Nitroso Compounds

Abstract In the presence of Na 2 CO 3 , conjugate addition of α-halo hydrazones to nitroso compounds proceeded readily to give polyfunctionalized nitrones in reasonable chemical yields and excellent stereoselectivities. The chemical structure and the stereochemical configuration of the products were...

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Bibliographic Details
Published in:Synlett 2021-09, Vol.32 (14), p.1457-1460
Main Authors: Bi, Xiao-Fan, Pang, Hai-Liang, Tang, Zhe, Zhang, Heng, Cai, Lu-Yu, Wu, Hui-Hui, Fan, Xiao-Zu, Zhao, Hong-Wu
Format: Article
Language:English
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Summary:Abstract In the presence of Na 2 CO 3 , conjugate addition of α-halo hydrazones to nitroso compounds proceeded readily to give polyfunctionalized nitrones in reasonable chemical yields and excellent stereoselectivities. The chemical structure and the stereochemical configuration of the products were unambiguously identified by an X-ray single-crystal structural analysis.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1509-0949