Synthesis of 1,3,4-Oxadiazoles by Iodine-Mediated Oxidative Cyclization of Methyl Ketones with 4-Phenylsemicarbazide

Abstract An efficient one-pot method has been developed to access 5-amino-2-(het)aroyl-1,3,4-oxadiazoles through I 2 /DMSO-promoted oxidative cyclization of 4-phenylsemicarbazide with (het)aryl methyl ketones under mild conditions. This reaction proceeds smoothly with a wide range of methyl ketones...

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Published in:Synlett 2022-02, Vol.33 (3), p.269-272
Main Authors: Zhang, Shanshan, Liu, Chuang, Wu, Xiaojun, Li, Wen, Li, He, Wang, Shiwei, Leng, Yuting, Wu, Yangjie
Format: Article
Language:English
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Summary:Abstract An efficient one-pot method has been developed to access 5-amino-2-(het)aroyl-1,3,4-oxadiazoles through I 2 /DMSO-promoted oxidative cyclization of 4-phenylsemicarbazide with (het)aryl methyl ketones under mild conditions. This reaction proceeds smoothly with a wide range of methyl ketones containing various functional groups to give the corresponding products in moderate yields under mild conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1707-0965