Ruthenium(II)-Catalyzed Selective C–H Bond Activation of Biindoles and Coupling with Sulfoxonium: An Efficient Access to Pyrido[1,2-a:4,3-b′]diindole frameworks

A ruthenium-catalyzed selective C–H functionalization/annulation cascade reaction of biindoles and sulfoxonium ylides has been developed. The reaction selectively provides pyrido[1,2-a:4,3-b′]diindole (5H-benzo[2,3]indolizino[7,8-b]indole) derivatives in good yields. A possible mechanism for the rea...

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Bibliographic Details
Published in:Synlett 2023-05, Vol.35 (7), p.811-815
Main Authors: Jatoth, Ramanna, Gugulothu, Kishan, Valappil, Rasika Meloth, Nelson, Nithya, Kumar, K. Shiva
Format: Article
Language:English
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Summary:A ruthenium-catalyzed selective C–H functionalization/annulation cascade reaction of biindoles and sulfoxonium ylides has been developed. The reaction selectively provides pyrido[1,2-a:4,3-b′]diindole (5H-benzo[2,3]indolizino[7,8-b]indole) derivatives in good yields. A possible mechanism for the reaction pathway is proposed. More importantly, the present study provides a useful method for the construction of pyrido[1,2-a:4,3-b′]diindole frameworks.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-2179-6438