Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent

Twenty novel 4-bromocoumarin derivatives bearing a sulfonamide moiety were designed and synthesized. Their antiviral and antibacterial activities were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. A...

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Published in:Synlett 2024-07
Main Authors: Bai, Song, Liu, Lin, Wu, Rong, Tang, Shouyin, Wan, Suran, Wang, Fang, Wei, Xian, Chen, Lijun, Xu, Shunyi, Li, Miao
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creator Bai, Song
Liu, Lin
Wu, Rong
Tang, Shouyin
Wan, Suran
Wang, Fang
Wei, Xian
Chen, Lijun
Xu, Shunyi
Li, Miao
description Twenty novel 4-bromocoumarin derivatives bearing a sulfonamide moiety were designed and synthesized. Their antiviral and antibacterial activities were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. Among all target compounds, one compound exhibited good antiviral activity against TMV, CMV, and PVY, which is superior to ribavirin. Moreover, two target compounds exhibited good in vitro antibacterial activity against Psa, with an EC50 value of 44.9 mg/L and 49.3 mg/L, respectively, which were better than thiodiazole copper and zinc thiazole, with an EC50 value of 56.3 mg/L and 50.2 mg/L, respectively. The results provide insights for the development of multifunctional pesticides.
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title Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent
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