Towards Metformin Prodrugs

Abstract The first examples of possible metformin prodrugs have been synthesized and characterized by spectroscopic methods. These five different types of chemically stable prodrugs were prepared from metformin and the corresponding halogenated promoieties. The products from unstable derivatives wer...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2008-11, Vol.2008 (22), p.3619-3624
Main Authors: Huttunen, Kristiina M., Leppänen, Jukka, Kemppainen, Eeva, Palonen, Piia, Rautio, Jarkko, Järvinen, Tomi, Vepsäläinen, Jouko
Format: Article
Language:English
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Summary:Abstract The first examples of possible metformin prodrugs have been synthesized and characterized by spectroscopic methods. These five different types of chemically stable prodrugs were prepared from metformin and the corresponding halogenated promoieties. The products from unstable derivatives were also identified and reasons for the rearrangements are discussed.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0028-1083603