N,N′-(Phenylmethylene)diacetamide Analogues as Economical and Efficient Ligands in Copper-Catalyzed Arylation of Aromatic Nitrogen-Containing Heterocycles

Abstract N,N′-(Phenylmethylene)diacetamide analogues which were simply prepared from the condensation reaction of an aldehyde with an amide or urea were found to be efficient ligands in copper-catalyzed coupling reaction of aryl halides with various azole nucleophiles. The newly developed ligand sho...

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Bibliographic Details
Published in:Synlett 2008-12, Vol.2008 (19), p.3068-3072
Main Authors: Wan, Jie-Ping, Chai, Yun-Feng, Wu, Jian-Mei, Pan, Yuan-Jiang
Format: Article
Language:English
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Summary:Abstract N,N′-(Phenylmethylene)diacetamide analogues which were simply prepared from the condensation reaction of an aldehyde with an amide or urea were found to be efficient ligands in copper-catalyzed coupling reaction of aryl halides with various azole nucleophiles. The newly developed ligand showed broad application scope in this conversion. Compounds including imidazoles, benzoimidazoles, pyrrole, indole, and benzotriazole were successfully arylated with diversified aromatic halides to give corresponding products in moderate to excellent yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0028-1087350