Practical Phosphorylation Methods for α,α-Disubstituted α-Amino Alcohol Derivatives

Abstract We report herein practical phosphorylation methods for α,α-disubstituted α-amino alcohol derivatives which act as S1P 1 receptor agonists. A novel direct phosphorylation method for α,α-di­substituted α-amino alcohol derivatives by biotransformation using CIRCINELLA MUSCAE, CIRCINELLA MINOR,...

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Bibliographic Details
Published in:Synlett 2009-04, Vol.2009 (6), p.910-912
Main Authors: Ohnuki, Takashi, Tsuji, Takashi, Miyazaki, Shojiro, Moriguchi, Taku, Nishi, Takahide
Format: Article
Language:English
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Summary:Abstract We report herein practical phosphorylation methods for α,α-disubstituted α-amino alcohol derivatives which act as S1P 1 receptor agonists. A novel direct phosphorylation method for α,α-di­substituted α-amino alcohol derivatives by biotransformation using CIRCINELLA MUSCAE, CIRCINELLA MINOR, CIRCINELLA MUCOROIDES, and CIRCINELLA UMBELLATE was developed. We applied the present method to the synthesis of phosphates of α,α-disubstituted α-amino alcohol derivatives.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0028-1087963