Efficacious Preparation of Oppolzer’s Glycylsultam via the Delépine Reaction

Abstract A new preparative route to Oppolzer’s glycylsultam, the ‘NC’ component in the asymmetric [C+NC+CC] coupling reaction leading to functionalized pyrrolidines, is described. The synthesis features a novel application of the Delépine reaction, providing a safe, efficient, and environmentally be...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2009-04, Vol.2009 (8), p.1261-1264
Main Authors: Isleyen, Alper, Gonsky, Carolyn, Ronald, Robert C., Garner, Philip
Format: Article
Language:English
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Summary:Abstract A new preparative route to Oppolzer’s glycylsultam, the ‘NC’ component in the asymmetric [C+NC+CC] coupling reaction leading to functionalized pyrrolidines, is described. The synthesis features a novel application of the Delépine reaction, providing a safe, efficient, and environmentally benign route to this useful chiral reagent for pyrrolidine synthesis.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0028-1088021