Synthesis of Glycosyltransferase Inhibitors

Abstract Glycosyltransferases and glycosidases work together to construct the oligosaccharide moieties of biologically active glycoconjugates. Although many excellent glycosidase inhibitors have been developed, some of which are in clinical use, there are relatively few promising candidates of glyco...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2009-10, Vol.2009 (19), p.3179-3210
Main Authors: Kajimoto, Tetsuya, Node, Manabu
Format: Article
Language:English
Subjects:
review
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Summary:Abstract Glycosyltransferases and glycosidases work together to construct the oligosaccharide moieties of biologically active glycoconjugates. Although many excellent glycosidase inhibitors have been developed, some of which are in clinical use, there are relatively few promising candidates of glycosyltransferase inhibitors. In this review, we summarize the current state of the development of glycosyltransferase inhibitors. 1 Introduction 2 Basic Strategy for Designing Glycosyltransferase Inhibitors 3 Sugar Nucleotide Analogues 4 Analogues of Acceptor Oligosaccharides (Acceptor Analogues) 5 Bisubstrate Inhibitors 6 High-Throughput Screening: Discovering Structurally Simple Inhibitors 7 Antisense Inhibitors 8 Questions and Future Directions
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0029-1216976