Straightforward Functionalization of 3,5-Dichloro-2-pyrazinones under Simultaneous Microwave and Ultrasound Irradiation

Abstract Heck reactions and Suzuki-Miyaura cross-couplings with relatively poorly reactive 3,5-dichloro-2-pyrazinones were studied at the same temperature under conventional heating, dielectric heating (MW) and simultaneous MW/US irradiation. This comparative study showed a synergic effect of combin...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2010-01, Vol.2010 (1), p.136-140
Main Authors: Garella, Davide, Tagliapietra, Silvia, Mehta, Vaibhav P., Van der Eycken, Erik, Cravotto, Giancarlo
Format: Article
Language:English
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Summary:Abstract Heck reactions and Suzuki-Miyaura cross-couplings with relatively poorly reactive 3,5-dichloro-2-pyrazinones were studied at the same temperature under conventional heating, dielectric heating (MW) and simultaneous MW/US irradiation. This comparative study showed a synergic effect of combined MW and US irradiation resulting in a much higher reaction yield, at the same time avoiding side reactions and partial degradation that is otherwise observed under conventional heating.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0029-1217065